| Paper ID | BIO-5.2 |
| Paper Title |
UNCERTAINTY-BASED BIOLOGICAL AGE ESTIMATION OF BRAIN MRI SCANS |
| Authors |
Karim Armanious, Sherif Abdulatif, Wenbin Shi, University of Stuttgart, Germany; Tobias Hepp, Max Planck Institute for Intelligent Systems, Germany; Sergios Gatidis, University of Tübingen, Germany; Bin Yang, University of Stuttgart, Germany |
| Session | BIO-5: Neuroimaging and Neural Signal Processing |
| Location | Gather.Town |
| Session Time: | Tuesday, 08 June, 14:00 - 14:45 |
| Presentation Time: | Tuesday, 08 June, 14:00 - 14:45 |
| Presentation |
Poster
|
| Topic |
Biomedical Imaging and Signal Processing: [BIO-MIA] Medical image analysis |
| IEEE Xplore Open Preview |
Click here to view in IEEE Xplore |
| Virtual Presentation |
Click here to watch in the Virtual Conference |
| Abstract |
Age is an essential factor in modern diagnostic procedures. However, assessment of the true biological age (BA) remains a daunting task due to the lack of reference ground-truth labels. Current BA estimation approaches are either restricted to skeletal images or rely on non-imaging modalities which yield a whole-body BA assessment. However, various organ systems may exhibit different aging characteristics due to lifestyle and genetic factors. In this initial study, we propose a new framework for organ-specific BA estimation utilizing 3D magnetic resonance image (MRI) scans. As a first step, this framework predicts the chronological age (CA) together with the corresponding patient-dependent aleatoric uncertainty. An iterative training algorithm is then utilized to segregate atypical aging patients from the given population based on the predicted uncertainty scores. In this manner, we hypothesize that training a new model on the remaining population should approximate the true BA behavior. We apply the proposed methodology on a brain MRI dataset containing healthy individuals as well as Alzheimer’s patients. We demonstrate the correlation between the predicted BAs and the expected cognitive deterioration in Alzheimer’s patients. |
